Dr. Upham works in the area of genetic toxicology and oncology. Current research projects involve determining the cellular mechanisms by which nutrition, oxidative stress, and environmental & food borne contaminants affect cell proliferative, differentiation and apoptotic processes that ultimately cumulates into states of human diseases such as cancer. Studies on cellular mechanisms focus primarily on how intracellular signal transduction pathways and gap junctional intercellular communication collaboratively orchestrate the epigenetic expression of genes in rodent and human stem cell model systems. These mechanistic based results are important in identifying molecular targets for chemoprevention, -intervention and -therapeutic strategies for the control of human diseases such as cancer. These results are also important in determining a more accurate assessment of risk of these chemicals on human health. He also use various in vitro bioassays of cell communication to estimate the risk of epigenetic toxicity of environmental toxicants in the design of engineered environmental remediation systems.